Research center

Etharums ser quidem rerum facilis dolores nemis omnis fugats vitaes nemo minima rerums unsers sadips amets.

Consultancy/Services

CEFTE offers comprehensive consultancy testing services for drugdevelopment using laboratory test systems viz. Rats, Mice, Rabbits,Guinea pigs, cell lines, human lymphocytes and bacterial strains

A. Toxicity /Safety testing B. Efficacy / Pharmacology testing

  • Toxicology services includes
    • Acute / Single dose toxicity
    • MTT and dose findings
    • Local toxicity studies- Skin / Eye / Mucous membrane
    • Skin sensitization- Guinea pig (GPMT/Buehlar)
    • Sub-acute / Sub-chronic toxicity (Repeated Dose 7/14/28/90 day )
    • Chronic toxicity - Repeated dose 180 day / one year
    • Carcinogenicity
    • Reproduction & developmental toxicity
    • Fertility, teratology, multi-generation studies
  • Genetic Toxicity services (OECD/ ISO 10993-3)
    • Bacterial Reverse Mutation Test (AMES)
    • In vitro and Invivo Micronucleus test
    • In vitro and Invivo Chromosomal aberration test
    • Mouse lymphoma assay
    • Comet assay
    • In Vitro Cytotoxicity (ISO 10993-5)
  • Biocompatibility Testing (Medical device)
  • Hemocompatibility Testing
  • Pharmacokinetics and Toxicokinetics
    • Single bolus - oral and intravenous route of administration
  • Bio-analytical Assays (Large Molecule)
    • Method development, validation and sample analysis as per EMA/FDA guidelines
  • Critical reagent production
    • Regular and Cascade immunization against Proteins, Peptides, Mixture of proteins, Fab fragments, Characterization by ELISA, Western, IHC, IF and Purification: Protein A/G, Affinity in Rat/Mouse, Rabbit, Guinea Pig, Goats
    • In vivo bioidentity testing of proteins and Peptides
    • Anti-sera (polyclonal/monoclonal) - Rat, Mice, Rabbit
  • Pharmacological /Disease models
    • Well-established and validated in vivo disease / screening models
    • Anxiety models (elevated plus maze, hole board,
    • Stress induced Hyperthermia
    • Cerebral stroke (middle cerebral artery occlusion, 4 vessel occlusion)
    • Depression (Chemical, behavioural CUMS, Stress induced LTD in Rat Hippocampus)
    • Epilepsy (pentylenetetrazole, picrotoxin, strychnine, Bicuculline, Beta- Carbolines, Guanidine etc)
    • Parkinsonism (MPTP model, 6-OHDA Unilateral Intrastriatal Lesion Model)
    • Huntington's disease (3-nitropropionic acid)
    • Alzheimer's disease (Scopolamine-induced amnesia, Aβ peptides infusion)
    • Gastric ulcer (Shay model, acetic acid/ ethanol induced, drugs induced)
    • Hepatic diseases (Paracetamol, anti-TB drugs, CCl4, Thioacetamide, Galactosamine, Azathioprine , concanavillin, Alcoholic / Non-Alcoholic Steatohepatitis)
  • Pharmacological services
    • Diabetes (alloxan, streptozotocin, high calorie / diet model, Dithizone, G-thioglucose genetic models)
    • Hyperlipidemia and obesity (triton WR 1339, high fat diet model)
    • Hypertension (2K/1C - renovascular, DOCA salt induced, Goldblatt, etc)
    • Cardiac toxicity (Doxorubicin, Anthramycin & Surgical models)
    • Myocardial infarction (isoproterenol model)
    • Immunology (Cell mediated and humoral mediated)
    • Inflammatory models (carrageenan, cotton pellet granuloma etc)
    • Rheumatoid arthritis (FCA model)
    • Tendonitis (Collagenase & Carrageenan)
    • Nootropics (radial arm maze, passive avoidance, transfer latency)
    • Pain models (formalin and acetic acid, vincristine, cisplatin, oxaliplatin, paclitaxel ,etc)
    • Stress induced LTD (Long Term Depression) in Hippocampus in rat
    • Post Surgical Pain model of mechanical hyperalgesia and allodynia in rat
    • Cancer Xenograft model