CEFTE offers comprehensive consultancy testing services for drugdevelopment using laboratory test systems viz. Rats, Mice, Rabbits,Guinea pigs, cell lines, human lymphocytes and bacterial strains
A. Toxicity /Safety testing B. Efficacy / Pharmacology testing
Toxicology services includes
Acute / Single dose toxicity
MTT and dose findings
Local toxicity studies- Skin / Eye / Mucous membrane
Skin sensitization- Guinea pig (GPMT/Buehlar)
Sub-acute / Sub-chronic toxicity (Repeated Dose 7/14/28/90 day )
Chronic toxicity - Repeated dose 180 day / one year
Carcinogenicity
Reproduction & developmental toxicity
Fertility, teratology, multi-generation studies
Genetic Toxicity services (OECD/ ISO 10993-3)
Bacterial Reverse Mutation Test (AMES)
In vitro and Invivo Micronucleus test
In vitro and Invivo Chromosomal aberration test
Mouse lymphoma assay
Comet assay
In Vitro Cytotoxicity (ISO 10993-5)
Biocompatibility Testing (Medical device)
Hemocompatibility Testing
Pharmacokinetics and Toxicokinetics
Single bolus - oral and intravenous route of administration
Bio-analytical Assays (Large Molecule)
Method development, validation and sample analysis as per EMA/FDA
guidelines
Critical reagent production
Regular and Cascade immunization against Proteins, Peptides,
Mixture of proteins, Fab fragments, Characterization by ELISA,
Western, IHC, IF and Purification: Protein A/G, Affinity in
Rat/Mouse, Rabbit, Guinea Pig, Goats
In vivo bioidentity testing of proteins and Peptides
Anti-sera (polyclonal/monoclonal) - Rat, Mice, Rabbit
Pharmacological /Disease models
Well-established and validated in vivo disease / screening models